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We are looking for a highly motivated, flexible and experienced scientist to join a team in the Bioanalysis, Immunogenicity and Biomarkers (BIB) department based in Collegeville, PA, USA. This role s primary responsibility is to develop and utilize assays for quantitative protein LC-MS analysis supporting pharmacokinetic (PK), critical quality attribute (CQA), and biotransformation for use in pre-clinical PK/PD/modeling studies and translation into the clinic in alignment with therapy area (TA) partners. Data generated serves as a key component to understanding molecules in the GSK pipeline and serves to enable confidence in drug discovery and development for biotherapeutic molecule screening and selection endpoints for early and informed decisions for asset progression within the organization. The successful candidate will provide analysis of novel biopharmaceutical constructs (e.g. proteins, peptides dAbs, mAbs, ADCs, bi-specifics) with first-hand experience applying state-of-art techniques such as immunoaffinity capture, high-resolution LC-MS, top-down and bottom-up protein analysis techniques, 2D-HPLC and automation.

Key Responsibilities:

  • Provide protein LC-MS expertise and senior lab-based assay support to the BIB organization
  • Be responsible for executing protein mass variant measurements to support pre-clinical and clinical studies; delivery of robust, high quality data packages and will demonstrate the ability to critique work to enable lead modalities to be smoothly progressed into clinical development
  • Serve on various Teams representing the BIB organization and advising on CQA strategy with the other analytical groups in the organization as well as TAs, thus providing in-depth, agnostic technological biotherapeutic quantitation assay expertise/advice while coordinating delivery of reagents, assays and data to ensure effective translation to the clinic.
  • Deliver, interpret and communicate complex scientific data to project/program teams in a timely manner
  • Ability to understand, interpret, and communicate complex scientific data to project teams
  • Track record of handling multiple projects concurrently
  • Willingness to develop and train others as required
  • Ability to function well in a team and possess a good balance of creative and analytical skills
  • Ability to handle human biological samples and performing experimental work in accordance with HBSM, safety and data integrity guidelines.
  • Why you?

    Basic Qualifications:

    We are looking for professionals with these required skills to achieve our goals:

  • MS with 10 years of industry experience or PhD with 2 years of experience.

  • An in-depth knowledge of quantitative protein LC-MS and a thorough understanding of the drug development process
  • Deep scientific expertise and strong laboratory hands-on experience with intact protein LC-MS, top-down protein characterization, and/or bottom-up protein characterization/proteomics. Demonstrated ability to use mass spectrometry to characterize post-translational modification of proteins.Familiarity with hybrid LC-MS/MS techniques and applications.
  • Attention to detail and effective communication and documentation skills will be expected.
  • Maintains a disciplined approach, ensuring a relentless focus on quality, compliance, scientific rigor and operational excellence
  • Highly motivated team player with a proactive attitude, excellent organizational skills and a demonstrated ability to interact effectively within a multi-disciplinary team are essential.
  • Preferred Qualifications:

    If you have the following characteristics, it would be a plus:

  • PhD in a related field
  • Why GSK?

    Our values and expectationsare at the heart of everything we do and form an important part of our culture.

    These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

  • Operating at pace and agile decision-making using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being.
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness.
  • If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK HR Service Centre at 1-877-###-#### (US Toll Free) or +1 801 ### #### (outside US).

    GSK is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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    * The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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